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KMID : 1084220160230050297
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Journal of Rheumatic Diseases
2016 Volume.23 No. 5 p.297 ~ p.303
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Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Expression in the Minor Salivary Glands of Sjogren’s Syndrome Patients
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Lee Kyung-Eun
Park Dong-Jin
Choi Sung-Eun
Kang Ji-Hyoun
Yim Yi-Rang
Kim Ji-Eun
Lee Jeong-Won
Wen Li-hui
Kim Tae-Jong
Park Yong-Wook
Lee Ji-Shin
Yoon Kyung-Chul
Lee Shin-Seok
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Abstract
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Objective. To evaluate the laboratory and clinical manifestations of Sjogren’s syndrome (SS) association with chemokine (C-X-C motif) ligand 1 (CXCL1) expression in the ductal and acinar salivary gland epithelial cells (SGEC) of the minor salivary glands.
Methods. The sociodemographic data of 106 SS patients was obtained, and the glandular and extraglandular manifestations of the disease documented. The minor salivary glands were biopsied and the laboratory findings analyzed. European League Against Rheumatism SS disease activity index (ESSDAI) and SS disease damage index (SSDDI) scores were obtained during biopsy. An immunohistochemical approach was used to define the expression of CXCL1 in the salivary glands.
Results. Of 106 patients, the minor salivary glands of 22 patients (20.7%) stained positively for CXCL1. Such CXCL1-positive patients exhibited higher ESSDAI scores at the time of biopsy than the CXCL1-negative patients (3.86±2.27 vs. 2.64±1.62, p=0.015). Lymphadenopathy was more frequently observed in CXCL1-positive patients, compared with CXCL1-negative patients (31.8% vs. 9.5%, p=0.014). No differences between groups were identified in terms of sociodemographic characteristics, laboratory data, or the extent of the glandular manifestation of SS.
Conclusion. The expression of CXCL1 within the ductal and acinar SGEC of SS patients is associated with lymphadenopathy and elevated clinical disease activity. CXCL1 may play an important role in the disease activity and prognosis of SS.
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KEYWORD
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Chemokines, CXCL1, Disease activity, Sjogren’s syndrome
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